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生命基礎科学(小林 正伸)

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研究実績

  • 著書
  • がんと向き合う−道民のための基礎知識 平成24年
  • 北海道新聞社
  • 著書(分担執筆)
  • がん原物質と造血器腫瘍のリスク(造血器腫瘍学—基礎と臨床の最新研究動向—)平成24年
  • 日本臨床 70巻 増刊号2 p39-42
  • 英文誌
  • Ohnishi S, et al. Hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors.
  • Plos one, 8, e66255
  • Kubo Y, Yanagawa Y, Matsumoto M, Hiraide S, Kobayashi M, Togashi H.
  • Toll-like receptor 7-mediated enhancement of contextual fear memory in mice.
  • Pharmacol Biochem Behav. 102:495-501, 2012.
  • Onuma K, Suenaga Y, Sakaki R, Yoshitome S, Sato Y, Ogawara S, Suzuki S, Kuramitsu Y, Yokoyama H, Murakami A, Hamada J, Nicolson GL, Kobayashi M, Fujii J, Okada F.
  • Development of a quantitative bioassay to assess preventive compounds against inflammation-based carcinogenesis.
  • Nitric Oxide 25:183-194, 2011
  • Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H,Sutherland LC, Brachmann RK.
  • 53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.
  • Int J Cancer 128:304-318, 2011.
  • Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.
  • Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization.
  • Int J Oncol. 2010 36:1379-86.
  • Kunishige Onuma, Yu Sato, Satomi Ogawara, Nobuyuki Shirasawa, Masanobu Kobayashi, Jun Yoshitake, Tetsuhiko Yoshimura, Masaaki Iigo, Junichi Fujii and Futoshi Okada.
  • Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells.
  • Am J Pathol.. 2009;175:2171-2183.
  • Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, S-C Yeung S-C and Lee M-H,
  • Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation,
  • Am J Pathol., 2009 175:400-11.
  • Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH.
  • Pim-1 plays a pivotal role in hypoxia-induced chemoresistance
  • Oncogene, 2009 28:2581-92.
  • Nakajima S, Niizeki H, Tada M, Nakagawa K, Kondo S, Okada F, Kobayashi M,
  • Trichostatin A with adenovirus-mediated p53 gene transfer synergistically inducesapoptosis in breast cancer cell line MDA-MB-231
  • Oncology Report, 2009 22:143-148
  • Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuti T, Kobayashi M.
  • All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors.
  • J of Immunol. 179:4616-4625, 2007.
  • Natsuizaka M, Ozasa M, Darmanin S, Miyamoto M, Kondo S, Kamada S, Shindoh M, Higashino F, Suhara W, Koide H, Aita K, Nakagawa K, Kondo T, Asaka M, Okada F and Kobayashi M.
  • Synergistic up-regulation of Hexokinase 2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose-deprivation and hypoxia.
  • Exp. Cell Res. 313:3337-48, 2007.
  • Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, Higashino F, Hamuro J, Okada F, Kobayashi M, Nakagawa K, Koide H, Kobayashi M.
  • Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin
  • Cancer Res. 67:3346-3355, 2007
  • Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui H-Y, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, and Kobayashi M,
  • Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist.
  • Cancer Gene Ther. 14:39-44、2007.

研究概要

がん原物質と造血器腫瘍のリスク

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